Twelve-month results of ab interno trabeculectomy with Kahook Dual Blade: an interventional, randomized, controlled clinical study

To evaluate the efficacy and safety profile of Kahook Dual Blade ab interno trabeculectomy combined with phacoemulsification compared to stand-alone conventional cataract surgery. A single-center longitudinal, randomized controlled trial was conducted. Patients older than 18 years coexisting open-angle glaucoma or ocular hypertension were invited participate. Preoperative postoperative clinical data collected analyzed preoperatively at months 1, 3, 6, 12 after procedure. Main outcome measures included best corrected visual acuity, intraocular pressure, number medications, endothelial cell count, standard automated perimetry. Forty-two eyes from 33 patients randomly allocated KDB (treatment, n = 21) alone (control, groups. Intraocular pressure decreased 17.9 ± 3.5 16.0 2.2 mmHg 17.3 2.5 15 3.2 last visit in treatment control groups (p 0.47). The use medications reduced a median (IQR) 1 (1–2) 0 (0–0) group (0–1) group, no significant differences between 12-month Best perimetry remained similar during follow-up both In well-controlled, mild-to-moderate glaucoma, adding might not be more effective reach mid-teens IOP values. Both procedures showed profiles. ClinicalTrials.gov Identifier: NCT04202562, December 17, 2019 retrospectively registered